Anti- inflammatory Medications

ANTI-INFLAMMATORY DRUGS

NSAIDs(non-steroidal anti-inflammatory drugs)- drugs with analgesic, antipyretic and in higher doses with anti inflammatory effects.

most prominent member of this group are as follows: aspirin, naproxen, ibuprofen

• Aspirin. it releives pain and reduces inflammation and fever. It is the world's most widely used drugs


• Naproxen. used to reduce inflammation and pain especially in the treatment of arthritis.


• Ibuprofen. used especially in the tx of arthritis and commonly taken for its antypyretic and anti inflammatory properties.

Mode of action:

NSAIDs acts as a non-selective inhibitor of the enzyme cyclooxygenase inhibiting both cyclooxygenase-1 and 2 isoenzymes. COX catalyzes the formation of prostagladins from arachidonic acid as messenger molecules in the process of inflammation.

Adverse effect:

• Direct and indirect irritation of the GI tract result in nausesa and vomiting, dyspepsia etc.
  
• nephrototoxicity


• CNS- seizure